Ketamine for PTSD
For PTSD, ketamine has been found to produce significant reductions in symptoms within 24 hours of infusion, with effects lasting up to two weeks. Multiple studies have shown that ketamine is more effective than a placebo in reducing PTSD symptoms. One study reported that 67% of patients receiving ketamine achieved at least a 30% reduction in symptoms after two weeks, compared to 20% with placebo.
How does ketamine work to help PTSD
Rapid Symptom Relief: Ketamine has been found to quickly reduce the severity of PTSD symptoms, which is crucial for patients experiencing acute distress. This rapid action can be lifesaving in emergency situations.
Mechanism of Action: Like its effects on depression and anxiety, ketamine’s action on NMDA receptors and its ability to enhance neuroplasticity are believed to help alleviate PTSD symptoms. It can also reduce inflammation and anxiety, which are often associated with PTSD.
Clinical Evidence: Studies have shown that repeated ketamine infusions can significantly reduce PTSD symptoms and maintain these improvements over several weeks. For instance, a study conducted by Mount Sinai found that repeated IV ketamine infusions significantly reduced symptom severity in individuals with chronic PTSD.
